{"id":148559,"date":"2023-11-23T14:54:02","date_gmt":"2023-11-23T09:24:02","guid":{"rendered":"https:\/\/www.oliveboard.in\/blog\/?p=148559"},"modified":"2023-11-23T14:54:04","modified_gmt":"2023-11-23T09:24:04","slug":"scientists-fabricate-2d-protein-monolayer-that-can-help-to-study-diseases-like-amyloidosis","status":"publish","type":"post","link":"https:\/\/www.oliveboard.in\/blog\/scientists-fabricate-2d-protein-monolayer-that-can-help-to-study-diseases-like-amyloidosis\/","title":{"rendered":"Scientists Fabricate 2D Protein Monolayer that can Help to Study Diseases Like Amyloidosis"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_77 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.oliveboard.in\/blog\/scientists-fabricate-2d-protein-monolayer-that-can-help-to-study-diseases-like-amyloidosis\/#More_About_the_News\" >More About the News<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.oliveboard.in\/blog\/scientists-fabricate-2d-protein-monolayer-that-can-help-to-study-diseases-like-amyloidosis\/#Physical_Properties_of_Lysozyme\" >Physical Properties of Lysozyme<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.oliveboard.in\/blog\/scientists-fabricate-2d-protein-monolayer-that-can-help-to-study-diseases-like-amyloidosis\/#Amyloidosis\" >Amyloidosis<\/a><\/li><\/ul><\/nav><\/div>\n\n<p>Scientists have successfully constructed a 2D protein monolayer by assembling lysozyme molecules. Lysozyme is a model protein frequently used in the study of diseases such as Amyloidosis. <\/p>\n\n\n\n<p>This innovative development involves arranging lysozyme molecules in a single layer, creating a 2D structure. The fabrication of this protein monolayer could have potential applications in various fields, particularly in advancing our understanding of protein behavior and diseases related to protein misfolding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"More_About_the_News\"><\/span>More About the News<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Researchers from the Institute of Advanced Study in Science and Technology, <a href=\"https:\/\/www.oliveboard.in\/blog\/guwahati-airport-introduces-digi-yatra-facility-to-elevate-air-travel\/\" target=\"_blank\" rel=\"noreferrer noopener\">Guwahati<\/a> (IASST), an autonomous institute in North-East India under the Department of Science and Technology (DST), have successfully assembled lysozyme molecules into a 2D monolayer at the interface of a pure aqueous subphase. Dr. Sarathi Kundu, Associate Professor, and Himadri Nath, a Junior Research Fellow, led the research group in utilizing the Langmuir-Blodgett (LB) technique to investigate the behavior of lysozyme molecules at air-water and air-solid interfaces. Lysozyme, being a model protein, aids in understanding diseases like Amyloidosis, which can lead to multi-organ dysfunction.<\/p>\n\n\n\n<p>Publication link:\u00a0<a href=\"https:\/\/doi.org\/10.1039\/D3RA03710J\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1039\/D3RA03710J<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Physical_Properties_of_Lysozyme\"><\/span>Physical Properties of Lysozyme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The research, recently published in RSC Advances by RSC publishers, delves into the investigation of the physical properties of lysozyme molecules at the air-water interface under varying surface pressure and subphase pH conditions. <\/li><li>The compressible behavior of lysozyme monolayers was correlated with the formation of stripe-like domains as surface pressure increased. <\/li><li>Studying lysozyme molecules at the air-water interface, along with their structural changes in variable pH conditions, serves as a model system for understanding Amyloidosis disease, which is associated with the misfolding and agglomeration of lysozyme molecules. <\/li><li>The closely packed lysozyme monolayers formed at the air-water and air-solid interfaces using the Langmuir-Blodgett method provide a platform for studying various chemical and physical properties in a 2D protein environment. <\/li><li>Additionally, the deposited LB films of lysozyme may be considered as protein nanotemplates for crystallizing proteins of interest.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Amyloidosis\"><\/span>Amyloidosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Amyloidosis is a rare group of diseases that occur when abnormal proteins called amyloid fibers build up in organs and tissues, leading to their dysfunction. These protein deposits can disrupt the normal function of organs such as the heart, kidneys, liver, spleen, nervous system, and digestive tract.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Types of Amyloidosis<\/h3>\n\n\n\n<p>There are several different types of amyloidosis, each caused by a different type of amyloid protein. Some of the most common types include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>AL amyloidosis:<\/strong> This is the most common type, accounting for about 50% of cases. It is caused by fragments of amyloid A protein, which is produced in excess in conditions such as rheumatoid arthritis and chronic inflammatory bowel disease.<\/li><li><strong>AA amyloidosis:<\/strong> This type is caused by a buildup of amyloid A protein in the body. It is often associated with chronic infections, such as tuberculosis and osteomyelitis.<\/li><li><strong>ATTR amyloidosis:<\/strong> This type is caused by a buildup of transthyretin protein in the body. It can be inherited or caused by a buildup of wild-type transthyretin protein in older men.<\/li><li><strong>Localized amyloidosis:<\/strong> This type is characterized by the buildup of amyloid protein in a specific organ or tissue, such as the skin, lungs, or bladder.<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Symptoms<\/h3>\n\n\n\n<p>The symptoms depend on the organs and tissues that are affected. Some common symptoms include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fatigue<\/li><li>Weakness<\/li><li>Weight loss<\/li><li>Shortness of breath<\/li><li>Swelling in the legs or ankles<\/li><li>Numbness or tingling in the hands or feet<\/li><li>Difficulty with memory or thinking<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Diagnosis<\/h3>\n\n\n\n<p>Diagnosing amyloidosis can be challenging because the symptoms can be vague and mimic those of other diseases. However, there are a number of tests that can help to diagnose amyloidosis, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood tests<\/li><li>Urine tests<\/li><li>Imaging tests, such as X-rays, CT scans, or MRIs<\/li><li>Tissue biopsy<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Treatment<\/h3>\n\n\n\n<p>The treatment depends on the type of amyloidosis and the organs that are affected. There is no cure for amyloidosis, but treatment can help to manage the symptoms and slow the progression of the disease. Treatment options may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medications to stop the production of amyloid protein<\/li><li>Stem cell transplantation<\/li><li>Organ transplantation<\/li><li>Supportive care, such as pain management and nutritional therapy<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Prognosis of Amyloidosis<\/h3>\n\n\n\n<p>The prognosis for amyloidosis varies depending on the type and the organs that are affected. With treatment, many people with amyloidosis can live for several years. However, amyloidosis can be a life-threatening disease, and some people with amyloidosis may not respond to treatment.<\/p>\n\n\n<ul class=\"wp-block-latest-posts__list is-grid columns-3 wp-block-latest-posts\"><li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/weekly-current-affairs\/\" aria-label=\"Weekly Current Affairs 2026 for Banking &amp; Other Govt Exams\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"67\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2025\/06\/weekly-current-affairs.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"weekly-current-affairs\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/weekly-current-affairs\/\">Weekly Current Affairs 2026 for Banking &amp; Other Govt Exams<\/a><\/li>\n<li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/monthly-current-affairs\/\" aria-label=\"Monthly Current Affairs 2026 PDF For SSC, Banking, and Railways\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"84\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2025\/06\/Monthly-Current-Affairs-2026-PDF.webp\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Monthly Current Affairs 2026 PDF\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/monthly-current-affairs\/\">Monthly Current Affairs 2026 PDF For SSC, Banking, and Railways<\/a><\/li>\n<li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/last-6-months-current-affairs-quiz\/\" aria-label=\"Last 6 Months&#8217; Current Affairs PDF &amp; Quiz: Nov 2025 to April 2026\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"84\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2026\/03\/Last-6-Months-Current-Affairs-LIVE-Quiz.webp\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/last-6-months-current-affairs-quiz\/\">Last 6 Months&#8217; Current Affairs PDF &amp; Quiz: Nov 2025 to April 2026<\/a><\/li>\n<li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/banking-financial-awareness-april-2026-quiz\/\" aria-label=\"Banking &amp; Financial Awareness April 2026 Quiz, FREE PDF\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"84\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2026\/05\/Banking-Financial-Awareness-April-2026-Quiz.webp\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Banking &amp; Financial Awareness April 2026 Quiz\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/banking-financial-awareness-april-2026-quiz\/\">Banking &amp; Financial Awareness April 2026 Quiz, FREE PDF<\/a><\/li>\n<li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/current-affairs-april-2026-quiz\/\" aria-label=\"Current Affairs April 2026 Quiz, Get Free PDF &amp; Attempt Live Quiz\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"84\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2026\/05\/Current-Affairs-April-2026-Quiz.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Current Affairs April 2026 Quiz\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/current-affairs-april-2026-quiz\/\">Current Affairs April 2026 Quiz, Get Free PDF &amp; Attempt Live Quiz<\/a><\/li>\n<li><div class=\"wp-block-latest-posts__featured-image\"><a href=\"https:\/\/www.oliveboard.in\/blog\/how-to-prepare-current-affairs-for-rbi-grade-b\/\" aria-label=\"How to Prepare Monthly Current Affairs for RBI Grade B?\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"84\" src=\"https:\/\/www.oliveboard.in\/blog\/wp-content\/uploads\/2026\/04\/RBI-Grade-B-3-1-1.webp\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" style=\"\" \/><\/a><\/div><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.oliveboard.in\/blog\/how-to-prepare-current-affairs-for-rbi-grade-b\/\">How to Prepare Monthly Current Affairs for RBI Grade B?<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Scientists have successfully constructed a 2D protein monolayer by assembling lysozyme molecules. Lysozyme is a model protein frequently used in<\/p>\n","protected":false},"author":54,"featured_media":148560,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10386,12871],"tags":[77],"class_list":["post-148559","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-affairs","category-november","tag-current-affairs","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Scientists Fabricate 2D Protein Monolayer that can Help to Study Diseases Like Amyloidosis<\/title>\n<meta name=\"description\" content=\"Scientists have successfully constructed a 2D protein monolayer by assembling lysozyme molecules. 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